Novel dna sequence of beta subunit of human thyroid stimulating hormone


PURPOSE:The titled sequence, having a base sequence coding beta type subunit of human thyroid stimulating hormone, usable for preparation of recombinant and giving the human stimulating hormone from microbial cells of a trans formant or culture fluid. CONSTITUTION:A novel DNA sequence coding beta type subunit (hTSHbeta) of a matured human thyroid stimulating hormone constituted of 112 amino acids. Preferably, the DNA sequence contains a DNA sequence coding a peptide of signal sequence constituted of 20 amino acids in at least the N (5') terminal and/or DNA sequence coding 6 hydrophobic amino acid sequences in the COOH (3') terminal. The sequence is capable of coding a polypeptide expressed by the formula.




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Cited By (7)

    Publication numberPublication dateAssigneeTitle
    EP-0228604-A2July 15, 1987Sloan-Kettering Institute For Cancer ResearchIsolation of a gene encoding human thyrotropin beta subunit
    EP-0228604-A3October 12, 1988Sloan-Kettering Institute For Cancer ResearchIsolation of a gene encoding human thyrotropin beta subunit
    JP-H04501802-AApril 02, 1992Us Health
    US-2011052591-A1March 03, 2011Board Of Regents Of The University Of Texas SystemVariants of Thyroid Stimulating Hormone Beta
    US-6284491-B1September 04, 2001The United States Of America As Represented By The Department Of Health And Human ServicesBiologically active synthetic thyrotropin and cloned gene for producing same
    WO-9820343-A2May 14, 1998B.R.A.H.M.S Diagnostica GmbhRezeptorbindungsassay, für den rezeptorbindungsassay geeigneter rekombinanter fusionsrezeptor, vektor zu dessen herstellung sowie reagenziensatz für die durchführung des rezeptorbindungsassays
    WO-9820343-A3July 16, 1998Brahms Diagnostica Gmbh, Ulrich Loos, Waldemar B MinichTest de liaison d'un recepteur, recepteur de fusion recombine approprie pour ce test, vecteur pour sa preparation et jeu de reactifs pour effectuer ce test